Genome-wide enhancer annotations differ significantly in genomic distribution, evolution, and function
نویسندگان
چکیده
منابع مشابه
Genome-wide identification of enhancer elements.
We present a prospective genome-wide regulatory element database for the sea urchin embryo and the modified chromosome capture-related methodology used to create it. The method we developed is termed GRIP-seq for genome-wide regulatory element immunoprecipitation and combines features of chromosome conformation capture, chromatin immunoprecipitation, and paired-end next-generation sequencing wi...
متن کاملGenomic conflict and genome evolution in Neurospora
Svedberg, J. 2017. Catching the Spore killers. Genomic conflict and genome evolution in Neurospora. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1561. 51 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0074-0. A genome is shaped by many different forces. Recombination can for instance both create and maintain genetic diversity,...
متن کاملPredicting CpG Islands and DNA Methlation in the Cow Genome Using DNA Microarray Meta-Analysis and Genome Wide Scanning
DNA methylation is a type of epigenetic changes that directly affects DNA. In mammals, DNA methylation is essential for fetal development and stem cell differentiation and this phenomenon essentially occurs within the CpG islands. In this study, two methods were used to study the DNA methylation profile of cow genome. In the first method, the DNA methylation profile of the differentially expres...
متن کاملA genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae.
The function of the vacuolar H(+)-ATPase (V-ATPase) enzyme complex is to acidify organelles; this process is critical for a variety of cellular processes and has implications in human disease. There are five accessory proteins that assist in assembly of the membrane portion of the complex, the V(0) domain. To identify additional elements that affect V-ATPase assembly, trafficking, or enzyme act...
متن کاملSwissRegulon: a database of genome-wide annotations of regulatory sites
SwissRegulon (http://www.swissregulon.unibas.ch) is a database containing genome-wide annotations of regulatory sites in the intergenic regions of genomes. The regulatory site annotations are produced using a number of recently developed algorithms that operate on multiple alignments of orthologous intergenic regions from related genomes in combination with, whenever available, known sites from...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Genomics
سال: 2019
ISSN: 1471-2164
DOI: 10.1186/s12864-019-5779-x